How might voters respond to a new policy? How would customers react to a product launch? What messages could escalate or defuse a crisis? Synthetic audience systems are changing how organizations test strategies, anticipate reactions, and refine decisions before they act. By simulating how specific populations interpret issues, messages, and scenarios, these tools can help leaders explore plausible futures, stress-test assumptions, surface blind spots, and identify where real-world validation is most needed. This panel will examine where synthetic audiences are already being deployed, what they can and cannot do, and how they can improve decision-making under uncertainty.